Science
Unique Mechanism of Action (MOA)
CrossBody platform constructs multi-specific antibodies with innovative fragment, featuring a unique mechanism of action (MOA), and making undruggable targets druggable
Modulating T Cell Binding to Mitigate CRS Risk
CrossBody technology offers exceptional flexibility in efficiently modulating both tumor and T cell binding (not affinity maturation) while retaining potent efficacy in tumor cells
TAA Concealment Strategy to Minimize On-target, Off-tumor Toxicity
The flexibility of CrossBody format enables the design of multi-specific antibodies with TAA concealment (not masked or caged), improving efficacy while reducing target-mediated toxicity in normal cells
Applications of CrossBody Platform
CrossBody platform could be applied to TCE, ADC, antibody-cytokine development for cancer, inflammatory, and autoimmune treatments